MSM, a silfur compound is essential for rejuvenation of the joints and the skin. I have up to 30 grams daily. I would have up to 100 grams if I could afford it. We start with half a gram per day, and icrease dragually, in order to avoid intestinal discomfort. MSM works best with vit. C and E, ginger, turmeric, glucosamine, chondroitine, Boswelia, bromelain, and hyaluronic acid. Take it at least with vit. C. I'm taking MSM with the XXL Nutrition glucosamine, vit C, vit E, turmeric and ginger. I take it with every meal or between meals. Now Foods joint stuf maybe worth looking into if you can't afford to take MSM with Animal Flex.